Application Notes

Action Potential (AP) MEA Recordings from Human iPSC-derived Cardiomyocytes After Acute and Chronic Exposure to Drugs

Foresee Biosystems srl

Publications

Advancing Cardiac Research: How Laser-Enabled MEA Technology Unlocks Action Potential Insights in Cardiac Organoids

Portugal G. Harvard Bioscience Blog, 2024

Long-term in vitro recording of cardiac action potentials on microelectrode arrays for chronic cardiotoxicity assessments

Iachetta, G., Melle, G., Colistra N., Tantussi F., De Angelis F., Dipalo M. Archives of Toxicology, Volume 97, 2023

Laser-Induced Action Potential-Like Measurements of Cardiomyocytes on Microelectrode Arrays for Increased Predictivity of Safety Pharmacology

Schaefer, J., Danker, T., Gebhardt, K., Kraushaar, U. (Indipendent Publication) Jove Journal, Volume 187, 2022

Improving reliability and reducing costs of cardiotoxicity assessments using laser-induced cell poration on microelectrode arrays

Iachetta G., Colistra N., Melle G., Deleye L. , Tantussi F., De Angelis F., Dipalo M. Toxicology and Applied Pharmacology, Volume 418, 2021

Plasmonic meta-electrodes allow intracellular recordings at network level on high-density CMOS-multi-electrode arrays

Dipalo, M., Melle, G., Lovato, L., Jacassi A., Caprettini V., Garoli D., Bruno G., Tantussi F., De Angelis F.  Nature Nanotechnology, Volume 13, 2018

Intracellular Recording of Human Cardiac Action Potentials on Market-Available Multielectrode Array Platforms

Melle G., Bruno G., Maccaferri N., Iachetta G., Colistra N., Barbaglia A., Dipalo M., De Angelis F., Frontiers in Bioengineering Biotechnology, 2020

Intracellular action potential recordings from cardiomyocytes by ultrafast pulsed laser irradiation of fuzzy graphene microelectrodes

Dipalo M., Rastogi S.K., Matino L., Garg R., Bliley J., Iachetta G., Melle G., Shrestha R., Shen S., Santoro F., Feinberg A.W., Barbaglia A., Cohen-Karni T., De Angelis F., Science Advances, Volume 7, 2021

Posters and Scientific Talks

Advancing cardiac 3D organoid-on-chip: integrating iPSC-derived MELAS syndrome models to study electromechanical synchronicity and cardiac memory using contactless technology

Margherita Burattini, Annalinda Pisano, Maria Gemma Pignataro, Michele Dipalo, Giuliana Orlandini, Carolina Scandellari, Vittoria Medeghini, Giovanni Battista Luciani, Gianluigi Condorelli, Giulia D’Amati, Michele Miragoli

1) University of Parma, Department of Medicine and Surgery, Parma, Italy 2) University of Verona, Department of Surgery, Dentistry and Maternity, Verona, Italy 3)University of La Sapienza,
Department of Radiological, Oncological and Anatomo-Pathological Sciences, Roma, Italy. 4) Foresee Biosystem s.r.l., Genova, Italy, 5) Humanitas Research Hospital — IRCCS, Rozzano
(Milan), Italy

High-throughput kinematic screening for cardiac organoids with impairment in contraction

Michele Miragoli, University of Parma

Evaluation of Laser Optoporation-Induced Action-Potential-Like Measurements on iPSC-Cardiomyocytes and the Assessment of Drug-Induced Effects on APD and
Contractility

Author: Jin Chang, Celogics Inc.

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