Drug toxicity, manifested also as cardiotoxicity, often generates drug attrition. Therefore, an early-stage detection of potential toxicity in drug discovery can save both time and developmental costs, and, most importantly, reduce the late-stage failure and potential withdrawn. Foresee biosystems exploits innovative solutions to assist you in understanding the toxic liability of your compounds, identifying which of them have the optimal safety profile to advance into the clinic. Our focus on LASER technology and automation allow for high quality data, generated rapidly and cost-effectively. To that end, Foresee biosystems provides you a service based on our LASER scanning technique to simultaneously measure cardiac action potential as indicators of cardiotoxicity, thus improving the prediction of toxicological effects on in-vitro cardiac cells model.
We offer an on-demand service to evaluate cardiotoxicity in human iPS cell-derived cardiomyocytes. Using microelectrode array and recording field potential, we determine whole cell electrophysiology measuring beat rate, field potential duration, amplitude and conduction velocity. Then, using the same microelectrode array coupled with Foresee technology, we provide the most precise and reliable in vitro assay, recording intracellular action potential that, different from the field potential, contains information about ions channels activity in the cell membrane, for the best assessment of cardiotoxicity actual on the market. Given the very low level of invasiveness of our technology, the Viability is maintained for an extended culture periods (up to 3 weeks) allowing for acute and chronic studies.
In accordance with customer requirements, we’ll provide a detailed report about the acute cardiotoxicity and chronic cardiotoxicity (see the example below). This cardiac assay provides a unique in vitro system for preclinical drug discovery, cardiotoxicity assessment, disease modelling and high throughput phenotypic screening of drug candidates
Foresee Service provides a cardiac safety assessment of chemicals, drug candidates and pollutants over a longer time frame. Besides acute drug effects (few minutes), our assay is capable of revealing chronic cytotoxicity and traffic inhibition of important cardiac ion channels such as hERG. Due to its cost-effectiveness and high throughput, this service is ideal for screening larger numbers of compounds.