Cardiac cells are grown on MEA electrodes until they reach a confluent beating monolayer. A single fast laser pulse is applied to the MEA electrode by the operator. The extremaly low invasive approach doesn’t affect cell beating frequency, enabling accurate Action Potential recordings from the cardiomyocyte grown on the electrode.
Melle, G., Bruno, G., Maccaferri, N., Iachetta, G., Colistra, N., Barbaglia, A., Dipalo, M., & De Angelis, F. (2020). Intracellular recording of human cardiac action potentials on market-available multielectrode array platforms. Frontiers in Bioengineering and Biotechnology